Higuchi connors phase solubility techniques.

Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added.Methods: Phase solubility studies revealed Bs type plots and stability constant was found to be 1868.79 kg/mol. Saturation solubility of binary complexes of CP with NS revealed marginal increase in saturation solubility in various media. An increase of 14.61% and 17.11% was evident in biorelevant media.Higuchi T, Connors K A 1965 Phase solubility techniques Advances in Analytical. Chemistry and Instrumentation vol 4(1) pp 117-212. 9. ITM Web of Conferences 45 ...Phase solubility stud ies were performed according to the method . reported by H iguchi and Connors [14]. Ex cess drug ... Higuchi T, Connors K. Phase-solubility techniques. Adv Anal

The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. The apparent solubility of DMA increased ...All the phase solubility diagrams displayed a typical AL type diagram (i.e. linear increases in luteolin solubility with increasing CD concentrations) within the concentration range studied, indicating a 1:1 stoichiometry of the complexes between luteolin and the five different CDs studied (Higuchi & Connors, 1965). This means that each ...[Article] - Phase Solubility Techniques I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv.

complexation is the phase so lubili ty method carr ied o ut according to Higuchi and Connors method [14][15] , which examines the e ffec t of nanospo nges on the solubility o f the drug. An

The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...In the present study, the solubility of aniracetam alone was 4.53 mg/mL. This is a significant increase from 0.109 mg/mL, which is reported in the literature . The marked increase in apparent solubility may be explained by the limited samples used within the phase solubility analysis at lower HP-β-CD concentrations.PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir. 31 Ağu 2017 ... The phase solubility studies were carried out to study the effect of cyclodextrins according to the method described by Higuchi and Connors. The ...Phase Solubility Study Figure No. 3. Phase-solubility profiles and classification of complexes. Higuchi and Connors [22] have classified complexes based their effect on substrate solubility as indicated by phase-solubility profiles (Figure 3). A-type phase-solubility profiles are obtained when the solubility of the substrate (i.e., drug ...

A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers. In vitro digestion showed that CDs protect the drug during digestion and even improve its bioaccessibility, and points to the need to protect roflumilast from light, suggesting that tablets containing the drug might be reformulated.

The solubility of CUR increased linearly with increasing concentrations of β-CD, represented as an A L type phase solubility curve (Higuchi & Connors, 1965; Jiang et al., 2019). The results of ANONA of the phase solubility model were provided in Table 1. F value (409.54) was extremely significant (p value < 0.001) suggesting that the model was ...

also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...method described by Higuchi and Connors (1965). Excess amounts of NB (5 mg) were ... Phase-solubility techniques. Adv Anal Chem Instrum 4: 117–212. Kadri M ...A stability indicating HPLC assay has been developed in order to investigate the effect of different factors on the stability of omeprazole. These factors included the pH with the tested values ranging from 6–10 and the temperature by monitoring the drug stability at 25, 37 and 40°C. The study was then extended to investigate the effect of ...Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117-212. Google Scholar

Phase solubility. Compatibility of host and guest relationship was determined by Higuchi-Connors phase solubility method [16]. Excess amount of drug was added in flask containing different molar ratios of βCD mixed in distilled water. Flasks were placed in water bath (TSSWB15-USA) at 37 ± 2 °C with speed of 100 rpm for 72 h.Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; Chemistry concentration of CD used (Higuchi & Connors, 1965). The Preparation of Complexes. The ... Phase-solubility techniques. Advances in Analytical Chemistry and.The effect of β-CD on the solubility of atorvastatin was investigated according to the phase solubility technique reported by Higuchi and Connors . Excess amounts of atorvastatin were added to 20 mL of either double-distilled water or aqueous solutions containing increasing concentrations of CDs, ranging from 5 to 15% w/w, in a …

Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, …

concentration of CD used (Higuchi & Connors, 1965). The Preparation of Complexes. The ... Phase-solubility techniques. Advances in Analytical Chemistry and.Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Etodolak’ın Ko-kristalizasyonu: Ko-kristalizasyon Tahmini, Ko-kristal Sentezi, Katı Faz Yapı Aydınlatma Çalışmaları ve In Vitro İlaç Salımı ... Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Show All References …The phase solubility study of CDL with PSC[4]arene and PSC[6]arene were executed according to Higuchi and Connors . Phase solubility studies were accomplished at 27 °C temperature, in triplicate. Excess quantity of CDL (250 mg) was added into different conical flasks containing 150 mL aqueous solutions of PSC[4]arene and PSC[6]arene at …The solubility of hydrocortisone (HC) was measured in water containing varying concentrations of γCD. The resulting B S-type phase-solubility diagram was described within the theoretical framework laid out by Higuchi and Connors. The initial linear increase in the solubility at low concentrations of γCD was caused by the formation of a water ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google ScholarHiguchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal Chem Instrum 4: 117 – 212. ICH Q6A Test procedures and acceptance criteria for newPhase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained …

7 May 2015 ... ... solubility method (Higuchi and Connors 1965). Figure 1 shows the phase ... Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal ...

Higuchi T, Connors K. Phase-solubility techniques. Adv Anal Chem Instrum. 1965;7:117–212. Google Scholar Jouyban A. Handbook of solubility data for pharmaceuticals. Boca Raton: CRC Press; 2009. United States Pharmacopeial Convention. USP 38–NF 33, General notices and requirements.

All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ...Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965). Assuming that the stoichiometry of the inclusion complex is 1:1, the solubility constant is given by the following equation: (1) K 1: 1 = s l o p e [T ...This was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ...Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0–4% (w/v) were added in volumetric flasks in a PBS …Nowadays the application of cyclodextrin-assisted molecular encapsulation in foods offers many advantages. Cyclodextrins, their derivatives and their cross-linked polymers can all improve the quality of food in storage, remove specific components and stabilize and increase the presence components that are important for a healthy diet.There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.To improve the dissolution rate of poorly water soluble drugs, several techniques were used such as particle size reduction (formation of micro- and nano-systems), formation of water soluble complexes [14] and amorphous solid dispersion preparations [15]. ... According to Higuchi an Connors phase-solubility diagram …The phase solubility study was performed in water as per the reported method by Higuchi and Connors . An excess amount of resveratrol was added to a solution containing an increasing concentration of nanosponges. ... Higuchi, T., Connors, K.A.: Phase solubility techniques. In: Advances Analytical Chemistry and Instrumentation, …Phase Solubility Studies. The determination of the phase solubility diagram is a widely accepted method for evaluation of the effect of cyclodextrin complexation on the drug solubility. The phase solubility studies were performed by the method reported by Higuchi and Connors . Increasing concentrations of MβCD (0–0.23 M) or …T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies

Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on a rotary shaker ...According to the phase-solubility diagram classification system that was introduced by Higuchi and Connors , linear A L-type diagrams show that the total drug solubility increases as a function of …The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …Phase solubility behavior was studied according to the method proposed by Higuchi and Connors ... Phase solubility techniques. Adv. Anal Chem Instrum 1965; 4: 117 ...Instagram:https://instagram. council bluffs craigslist petsradical zionistdonatos east broad stpassed out drunks Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, …Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added. where is gregg marshall now 2022mitch lightfoot nba T. Higuchi, A. Connors Published 1965 Chemistry No Paper Link Available Save to Library Create Alert Cite 2,644 Citations Citation Type More Filters Environmentally friendly stability-indicating HPLC method for the determination of isotretinoin in commercial products and solubility samples health and science degree Solubility diagrams exhibit AL type according to the Higuchi and Connors classification [23], showing a linear increase ... Phase-solubility techniques. Adv Anal ...To improve the dissolution rate of poorly water soluble drugs, several techniques were used such as particle size reduction (formation of micro- and nano-systems), formation of water soluble complexes [14] and amorphous solid dispersion preparations [15]. ... According to Higuchi an Connors phase-solubility diagram …